The majestic Durbar Hall of the Institute was decorated specially for felicitation of Prince of Wales during his visit in 1875 to the then Governor's House. A commemorative painting of the Hall during this period depicting a royal ball still hangs in the Hall.

When the Governor's House was handed over to Haffkine for starting a Research Institute, the Hall was used to house the treasure of medical literature as a library and also an auditorium for scientific conventions. Many great scientists like C.V. Raman have delivered scientific orations here.

In 1990, a separate two storied building was constructed to accommodate the huge archival collections of books and journals and since, then the Hall is exclusively used for holding lectures and training programmes.

The spacious & regal Hall measures 35m x 10m and has a great height of 7.5m. It has a sitting capacity of 250 and is well equipped with modern audiovisual equipment like high quality amplifying system, overhead projector, slide projector and a LCD projector.