|
Testing
Activities
The department
undertakes various acute toxicological tests on
drugs, chemicals, cosmetics, foods and other products
as per the regulatory requirements for each category
of such products. The acute toxicity tests undertaken
are as under:
Toxicological
Tests
|
1.
|
Acute
toxicity (LD50) in mice by oral and systemic
routes. Acute toxicity (LD50) in rats by oral
and systemic routes. |
|
|
|
|
2.
|
Acute
toxicity (LD50) of substances dissolved in
water on fish.(environmental toxicity on aquatic
life) |
|
|
|
|
3.
|
Primary
dermal irritation in rabbits by Draize technique
on topical formulations, cosmetics and materials. |
|
|
|
|
4.
|
Primary
dermal irritation in rabbits by modified Draize
technique on topical formulations, cosmetics
and materials. |
|
|
|
|
5.
|
Mucous
membrane irritation effect in rabbits. |
|
|
|
|
6.
|
Skin
sensitisation effect in guinea pigs. |
|
|
|
|
7.
|
Toxicity
studies on containers used for storage of
water. |
Bioavailability
studies
|
1.
|
Bioavailability and bioequivalence
studies on pharmaceutical oral dosage forms
of drugs. |
|
|
|
|
2.
|
Bioequivalence studies
on topical formulations of drugs like corticoid
creams and gels. |
|
|
|
|
3.
|
Bioavailability studies
on modified-release, sustained-release and
extended-release dosage forms of drugs. |
| |
|
|
